Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection--a case report.

Zecca, Chiara; Mainetti, Carlo; Blum, Roland; Gobbi, Claudio (2015). Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection--a case report. BMC neurology, 15(249), p. 249. BioMed Central 10.1186/s12883-015-0504-0

Preview

Text Blum 1.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview

BACKGROUND

Glatiramer acetate is worldwide used as first line treatment in relapsing remitting multiple sclerosis. Local skin reactions associated with glatiramer acetate are common, however, only isolated cases of severe local injection site reactions known as Nicolau Syndrome have been reported so far.

CASE PRESENTATION

We describe the case of a recurrent Nicolau Syndrome occurred during longstanding glatiramer acetate treatment in a woman with multiple sclerosis. The haemorrhagic patch necrotized and was treated locally as a deep second degree burn with excision of dead skin tissue and was healed. Treatment with glatiramer acetate was definitely suspended.

CONCLUSIONS

GA injections can be complicated by isolated or recurrent Nicolau Syndrome, a potentially life-threatening condition of which neurologists should be aware.

Interest & Impact

Downloads

162 since deposited on 19 Feb 2016
11 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item