Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy.

Summerfield, Artur; Ruggli, Nicolas (2015). Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy. Frontiers in veterinary science, 2, p. 10. Frontiers Media 10.3389/fvets.2015.00010

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Classical swine fever virus infection of pigs causes disease courses from life-threatening to asymptomatic, depending on the virulence of the virus strain and the immunocompetence of the host. The virus targets immune cells, which are central in orchestrating innate and adaptive immune responses such as macrophages and conventional and plasmacytoid dendritic cells. Here, we review current knowledge and concepts aiming to explain the immunopathogenesis of the disease at both the host and the cellular level. We propose that the interferon type I system and in particular the interaction of the virus with plasmacytoid dendritic cells and macrophages is crucial to understand elements governing the induction of protective rather than pathogenic immune responses. The review also concludes that despite the knowledge available many aspects of classical swine fever immunopathogenesis are still puzzling.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Summerfield, Artur and Ruggli, Nicolas

Subjects:

600 Technology > 630 Agriculture

ISSN:

2297-1769

Publisher:

Frontiers Media

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

02 Mar 2016 11:51

Last Modified:

26 Jun 2016 02:12

Publisher DOI:

10.3389/fvets.2015.00010

PubMed ID:

26664939

Uncontrolled Keywords:

classical swine fever, dendritic cells, interferon, macrophages, virulence

BORIS DOI:

10.7892/boris.76856

URI:

https://boris.unibe.ch/id/eprint/76856

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