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Avanthay, Robin; Garcia Nicolas, Obdulio; Ruggli, Nicolas; Grau Roma, Llorenç; Párraga-Ros, Ester; Summerfield, Artur; Zimmer, Gert (2024). Evaluation of a novel intramuscular prime/intranasal boost vaccination strategy against influenza in the pig model. PLoS pathogens, 20(8) Public Library of Science 10.1371/journal.ppat.1012393
Torres Puig, Sergi; Crespo Pomar, Silvia; Akarsu, Hatice; Yimthin, Thatcha; Cippà, Valentina; Démoulins, Thomas; Posthaus, Horst; Ruggli, Nicolas; Kuhnert, Peter; Labroussaa, Fabien; Jores, Jörg (2024). Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis. Communications biology, 7(779) Springer Nature 10.1038/s42003-024-06497-8
Jores, Jörg; Ruggli, Nicolas; Scalisi, Nadia; Jang, Jaeyoun; Torres-Puig, Sergi (2024). A stress-free and easy-to-use system to expose pigs to aerosols. Vaccine: X, 17(100457) Elsevier 10.1016/j.jvacx.2024.100457
Hinojosa, Yoandry; Liniger, Matthias; Garciá-Nicolás, Obdulio; Gerber, Markus; Rajaratnam, Anojen; Muñoz-González, Sara; Coronado, Liani; Frías, María Teresa; Perera, Carmen Laura; Ganges, Llilianne; Ruggli, Nicolas (2024). Evolutionary-Related High- and Low-Virulent Classical Swine Fever Virus Isolates Reveal Viral Determinants of Virulence. Viruses, 16(1) MDPI 10.3390/v16010147
Mehinagic, Kemal; Liniger, Matthias; Samoilenko, Maksym; Soltermann, Nick; Gerber, Markus; Ruggli, Nicolas (2024). A Sensitive Luciferase Reporter Assay for the Detection of Infectious African Swine Fever Virus. Journal of virological methods, 323, p. 114854. Elsevier 10.1016/j.jviromet.2023.114854
Démoulins, Thomas; Techakriengkrai, Navapon; Ebensen, Thomas; Schulze, Kai; Liniger, Matthias; Gerber, Markus; Nedumpun, Teerawut; McCullough, Kenneth C; Guzmán, Carlos A; Suradhat, Sanipa; Ruggli, Nicolas (2024). New Generation Self-Replicating RNA Vaccines Derived from Pestivirus Genome. Methods in molecular biology, 2786, pp. 89-133. Springer 10.1007/978-1-0716-3770-8_4
Kristen-Burmann, Claudia; Rogger, Peter; Berenguer Veiga, Inês; Riebesehl, Stefanie; Rappe, Julie; Ebert, Nadine; Sautter, Carmen A; Kelly, Jenna N; Stalder, Hanspeter; Ehmann, Rosina; Huber, Michael; Posthaus, Horst; Ruggli, Nicolas; Thiel, Volker; Tekes, Gergely (2023). Reverse Genetic Assessment of the Roles Played by the Spike Protein and ORF3 in Porcine Epidemic Diarrhea Virus Pathogenicity. Journal of virology, 97(7), e0196422. American Society for Microbiology 10.1128/jvi.01964-22
Démoulins, Thomas; Schulze, Kai; Ebensen, Thomas; Techakriengkrai, Navapon; Nedumpun, Teerawut; Englezou, Pavlos C; Gerber, Markus; Hlushchuk, Ruslan; Toledo, Darien; Djonov, Valentin; von Gunten, Stephan; McCullough, Kenneth C; Liniger, Matthias; Guzmán, Carlos A; Suradhat, Sanipa; Ruggli, Nicolas (2023). Coatsome-replicon vehicles: Self-replicating RNA vaccines against infectious diseases. Nanomedicine : nanotechnology, biology, and medicine, 49(102655), p. 102655. Elsevier 10.1016/j.nano.2023.102655
Démoulins, Thomas; Brügger, Melanie; Zumkehr, Beatrice; Oliveira Esteves, Blandina I; Ruggli, Nicolas; Alves, Marco (2022). Multiparameter flow cytometry assay to analyze the pulmonary T cell profiles in the ovine model of respiratory syncytial virus infection. STAR protocols, 3(4), p. 101688. Elsevier 10.1016/j.xpro.2022.101688
Radulovic, Emilia; Mehinagic, Kemal; Wüthrich, Tsering; Hilty, Markus; Posthaus, Horst; Summerfield, Artur; Ruggli, Nicolas; Benarafa, Charaf (2022). The baseline immunological and hygienic status of pigs impact disease severity of African swine fever. PLoS pathogens, 18(8), e1010522. Public Library of Science 10.1371/journal.ppat.1010522
Wang, Miaomiao; Bohórquez, José Alejandro; Muñoz-González, Sara; Gerber, Markus; Alberch, Mònica; Pérez-Simó, Marta; Abad, Xavier; Liniger, Matthias; Ruggli, Nicolas; Ganges, Llilianne (2022). Removal of the Erns RNase Activity and of the 3' Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease. Journal of virology, 96(14), e0043822. American Society for Microbiology 10.1128/jvi.00438-22
Scalisi, Nadia; Kuhnert, Peter; Amado, Maria Elena Vargas; Overesch, Gudrun; Stärk, Katharina D C; Ruggli, Nicolas; Jores, Joerg (2022). Seroprevalence of Mycoplasma hyopneumoniae in sows fifteen years after implementation of a control programme for enzootic pneumonia in Switzerland. Veterinary microbiology, 270, p. 109455. Elsevier 10.1016/j.vetmic.2022.109455
Wang, Miaomiao; Bohórquez, José Alejandro; Hinojosa, Yoandry; Muñoz-González, Sara; Gerber, Markus; Coronado, Liani; Perera, Carmen Laura; Liniger, Matthias; Ruggli, Nicolas; Ganges, Llilianne (2021). Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs. Virulence, 12(1), pp. 2037-2049. Taylor & Francis 10.1080/21505594.2021.1959715
Labroussaa, Fabien; Mehinagic, Kemal; Cippa, Valentina; Liniger, Matthias; Akarsu, Hatice; Ruggli, Nicolas; Jores, Joerg (2021). In-yeast reconstruction of the African swine fever virus genome isolated from clinical samples. STAR protocols, 2(3), p. 100803. Elsevier 10.1016/j.xpro.2021.100803
Gultom, Mitra; Licheri, Matthias; Laloli, Laura; Wider, Manon; Strässle, Marina; V'kovski, Philip; Steiner, Silvio; Kratzel, Annika; Tran, Thi Nhu Thao; Probst, Lukas; Stalder, Hanspeter; Portmann, Jasmine; Holwerda, Melle; Ebert, Nadine; Stokar-Regenscheit, Nadine; Gurtner, Corinne; Zanolari, Patrik; Posthaus, Horst; Schuller, Simone; Vicente-Santos, Amanda; ... (2021). Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2. Emerging infectious diseases, 27(7), pp. 1811-1820. Centers for Disease Control and Prevention 10.3201/eid2707.204660
Brügger, Melanie; Démoulins, Thomas; Barut, G. Tuba; Zumkehr, Beatrice; Oliveira Esteves, Blandina I.; Mehinagic, Kemal; Haas, Quentin; Schögler, Aline; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Moehrlen, Ueli; Marti, Thomas M.; Schmid, Ralph A.; Summerfield, Artur; Posthaus, Horst; Ruggli, Nicolas; Hall, Sean R. R.; Alves, Marco P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS pathogens, 17(7), e1009789. Public Library of Science 10.1371/journal.ppat.1009789
Démoulins, Thomas; Brügger, Melanie; Zumkehr, Beatrice; Oliveira Esteves, Blandina I; Mehinagic, Kemal; Fahmi, Amal; Borcard, Loïc; Taddeo, Adriano; Jandrasits, Damian; Posthaus, Horst; Benarafa, Charaf; Ruggli, Nicolas; Alves, Marco P (2021). The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis. PLoS pathogens, 17(4), e1009529. Public Library of Science 10.1371/journal.ppat.1009529
Welner, Simon; Ruggli, Nicolas; Liniger, Matthias; Summerfield, Artur; Larsen, Lars Erik; Jungersen, Gregers (2021). Reduced Virus Load in Lungs of Pigs Challenged with Porcine Reproductive and Respiratory Syndrome Virus after Vaccination with Virus Replicon Particles Encoding Conserved PRRSV Cytotoxic T-Cell Epitopes. Vaccines, 9(3) MDPI 10.3390/vaccines9030208
Démoulins, Thomas; Ruggli, Nicolas; Gerber, Markus; Thomann-Harwood, Lisa J; Ebensen, Thomas; Schulze, Kai; Guzmán, Carlos A; McCullough, Kenneth C (2021). Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs. Frontiers in immunology, 11, p. 622385. Frontiers Research Foundation 10.3389/fimmu.2020.622385
Liniger, Matthias; Gerber, Markus; Renzullo, Sandra; Garcia-Nicolás, Obdulio; Ruggli, Nicolas (2021). TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent. Viruses, 13(10), p. 2017. MDPI 10.3390/v13102017
Ganges, Llilianne; Crooke, Helen R; Bohórquez, Jose Alejandro; Postel, Alexander; Sakoda, Yoshihiro; Becher, Paul; Ruggli, Nicolas (2020). Classical swine fever virus: the past, present and future. Virus research, 289, p. 198151. Elsevier 10.1016/j.virusres.2020.198151
Warryn, Louisa; Dangy, Jean-Pierre; Gersbach, Philipp; Gehringer, Matthias; Schäfer, Anja; Ruf, Marie-Thérèse; Ruggli, Nicolas; Altmann, Karl-Heinz; Pluschke, Gerd (2020). Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans. PLoS neglected tropical diseases, 14(6), e0008357. Public Library of Science 10.1371/journal.pntd.0008357
Hüppi, Linda; Ruggli, Nicolas; Python, Sylvie; Hoop, Richard; Albini, Sarah; Grund, Christian; Vögtlin, Andrea (2020). Experimental pigeon paramyxovirus-1 infection in chicken: evaluation of infectivity, clinical and pathological manifestations and diagnostic methods. The journal of general virology, 101(2), pp. 156-167. Microbiology Society 10.1099/jgv.0.001364
Itakura, Yukari; Matsuno, Keita; Ito, Asako; Gerber, Markus; Liniger, Matthias; Fujimoto, Yuri; Tamura, Tomokazu; Kameyama, Ken-Ichiro; Okamatsu, Masatoshi; Ruggli, Nicolas; Kida, Hiroshi; Sakoda, Yoshihiro (2020). A cloned classical swine fever virus derived from the vaccine strain GPE- causes cytopathic effect in CPK-NS cells via type-I interferon-dependent necroptosis. Virus research, 276, p. 197809. Elsevier 10.1016/j.virusres.2019.197809
Wang, Miaomiao; Liniger, Matthias; Muñoz-González, Sara; Bohórquez, José Alejandro; Hinojosa, Yoandry; Gerber, Markus; López-Soria, Sergio; Rosell, Rosa; Ruggli, Nicolas; Ganges, Llilianne (2020). A Polyuridine Insertion in the 3' Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets. Journal of virology, 94(2) American Society for Microbiology 10.1128/JVI.01214-19
Auray, Gael; Talker, Stephanie; Keller, Irene; Python, Sylvie; Gerber, Markus; Liniger, Matthias; Ganges, Llilianne; Bruggmann, Rémy; Ruggli, Nicolas; Summerfield, Artur (2020). High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo. Frontiers in immunology, 11, p. 1429. Frontiers Research Foundation 10.3389/fimmu.2020.01429
Xie, Jiexiong; Trus, Ivan; Oh, Dayoung; Kvisgaard, Lise K; Rappe, Julie C.F.; Ruggli, Nicolas; Vanderheijden, Nathalie; Larsen, Lars E; Lefèvre, François; Nauwynck, Hans J (2019). A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells. Viruses, 11(1) MDPI 10.3390/v11010036
Rappe, Julie Christiane Françoise; de Wilde, Adriaan; Di, Han; Müller, Christin; Stalder, Hanspeter; V'Kovski, Philip; Snijder, Eric; Brinton, Margo A; Ziebuhr, John; Ruggli, Nicolas; Thiel, Volker Earl (2018). Antiviral activity of K22 against members of the order Nidovirales. Virus research, 246, pp. 28-34. Elsevier 10.1016/j.virusres.2018.01.002
Demoulins, Thomas; Ebensen, Thomas; Schulze, Kai; Englezou, Pavlos; Pelliccia, Maria; Guzmán, Carlos A; Ruggli, Nicolas; McCullough, Kenneth (2017). Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure. Journal of controlled release, 266, pp. 256-271. Elsevier 10.1016/j.jconrel.2017.09.018
Ricklin, Meret; Python, Sylvie; Vielle, Nathalie Jane; Brechbühl, Daniel; Zumkehr, Béatrice; Posthaus, Horst; Zimmer, Gert; Ruggli, Nicolas; Summerfield, Artur (2017). Virus replicon particle vaccines expressing nucleoprotein of influenza A virus mediate enhanced inflammatory responses in pigs. Scientific Reports, 7(1), p. 16379. Nature Publishing Group 10.1038/s41598-017-16419-w
Coronado, Liani; Liniger, Matthias; Muñoz-González, Sara; Postel, Alexander; Pérez, Lester Josue; Pérez-Simó, Marta; Perera, Carmen Laura; Frías-Lepoureau, Maria Teresa; Rosell, Rosa; Grundhoff, Adam; Indenbirken, Daniela; Alawi, Malik; Fischer, Nicole; Becher, Paul; Ruggli, Nicolas; Ganges, Llilianne (2017). Novel poly-uridine insertion in the 3'UTR and E2 amino acid substitutions in a low virulent classical swine fever virus. Veterinary microbiology, 201, pp. 103-112. Elsevier 10.1016/j.vetmic.2017.01.013
Demoulins, Thomas; Englezou, Pavlos; Milona, Panagiota; Ruggli, Nicolas; Tirelli, Nicola; Pichon, Chantal; Sapet, Cédric; Ebensen, Thomas; Guzmán, Carlos A; McCullough, Kenneth (2017). Self-Replicating RNA Vaccine Delivery to Dendritic Cells. In: RNA Vaccines. Methods in molecular biology: Vol. 1499 (pp. 37-75). Springer 10.1007/978-1-4939-6481-9_3
Auray, Gael; Keller, Irene; Python, Sylvie; Gerber, Markus Daniel; Bruggmann, Rémy; Ruggli, Nicolas; Summerfield, Artur (2016). Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences. Journal of immunology, 197(12), pp. 4791-4806. American Association of Immunologists 10.4049/jimmunol.1600672
Rappe, Julie Christiane Françoise; Garcia Nicolas, Obdulio; Flückiger, Franziska; Thür, Barbara; Hofmann, Martin A; Summerfield, Artur; Ruggli, Nicolas (2016). Heterogeneous antigenic properties of the porcine reproductive and respiratory syndrome virus nucleocapsid. Veterinary research, 47(1), p. 117. Editions scientifiques Elsevier 10.1186/s13567-016-0399-9
Gottipati, Keerthi; Holthauzen, Luis Marcelo F; Ruggli, Nicolas; Choi, Kyung H (2016). Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. Journal of virology, 90(17), pp. 7740-7747. American Society for Microbiology 10.1128/JVI.00318-16
Bolz, Miriam; Ruggli, Nicolas; Borel, Nicole; Pluschke, Gerd; Ruf, Marie-Thérèse (2016). Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model. PLoS neglected tropical diseases, 10(4), e0004678. Public Library of Science 10.1371/journal.pntd.0004678
Eck, Melanie; Durán, Margarita García; Ricklin, Meret; Locher, Samira; Sarraseca, Javier; Rodríguez, María José; McCullough, Kenneth; Summerfield, Artur; Zimmer, Gert; Ruggli, Nicolas (2016). Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs. Veterinary research, 47(33), p. 33. BioMed Central 10.1186/s13567-016-0318-0
Garcia Nicolas, Obdulio; Auray, Gael; Sautter, Carmen Alexandra Nadine; Rappe, Julie Christiane Françoise; McCullough, Kenneth; Ruggli, Nicolas; Summerfield, Artur (2016). Sensing of Porcine Reproductive and Respiratory Syndrome Virus-Infected Macrophages by Plasmacytoid Dendritic Cells. Frontiers in Microbiology, 7(771), p. 771. Frontiers 10.3389/fmicb.2016.00771
Demoulins, Thomas; Milona, Panagiota; Englezou, Pavlos; Ebensen, Thomas; Schulze, Kai; Suter, Rolf; Pichon, Chantal; Midoux, Patrick; Guzmán, Carlos A; Ruggli, Nicolas; McCullough, Kenneth (2015). Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines. Nanomedicine : nanotechnology, biology, and medicine, 12(3), pp. 711-722. Elsevier 10.1016/j.nano.2015.11.001
Tamura, Tomokazu; Ruggli, Nicolas; Nagashima, Naofumi; Okamatsu, Masatoshi; Igarashi, Manabu; Mine, Junki; Hofmann, Martin A; Liniger, Matthias; Summerfield, Artur; Kida, Hiroshi; Sakoda, Yoshihiro (2015). Intracellular membrane association of the N-terminal domain of classical swine fever virus NS4B determines viral genome replication and virulence. Journal of general virology, 96(9), pp. 2623-2635. Society for General Microbiology 10.1099/vir.0.000200
Mine, Junki; Tamura, Tomokazu; Mitsuhashi, Kazuya; Okamatsu, Masatoshi; Parchariyanon, Sujira; Pinyochon, Wasana; Ruggli, Nicolas; Tratschin, Jon-Duri; Kida, Hiroshi; Sakoda, Yoshihiro (2015). The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production. Journal of general virology, 96(Pt 7), pp. 1746-1756. Society for General Microbiology 10.1099/vir.0.000132
Summerfield, Artur; Ruggli, Nicolas (2015). Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy. Frontiers in veterinary science, 2, p. 10. Frontiers Media 10.3389/fvets.2015.00010
Muñoz-González, Sara; Perez-Simó, Marta; Muñoz, Marta; Bohorquez, José Alejandro; Rosell, Rosa; Summerfield, Artur; Domingo, Mariano; Ruggli, Nicolas; Ganges, Llilianne (2015). Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs. Veterinary research, 46(1), p. 78. Editions scientifiques Elsevier 10.1186/s13567-015-0209-9
Muñoz-González, Sara; Ruggli, Nicolas; Rosell, Rosa; Pérez, Lester Josué; Frías-Leuporeau, Maria Teresa; Fraile, Lorenzo; Montoya, Maria; Cordoba, Lorena; Domingo, Mariano; Ehrensperger, Felix; Summerfield, Artur; Ganges, Llilianne (2015). Postnatal persistent infection with classical Swine Fever virus and its immunological implications. PLoS ONE, 10(5), e0125692. Public Library of Science 10.1371/journal.pone.0125692
Mokhtar, Helen; Eck, Melanie; Morgan, Sophie B; Essler, Sabine E; Frossard, Jean-Pierre; Ruggli, Nicolas; Graham, Simon P (2014). Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity. Vaccine, 32(50), pp. 6828-6837. Elsevier 10.1016/j.vaccine.2014.04.054
McCullough, Kenneth C.; Milona, Panagiota; Thomann-Harwood, Lisa; Demoulins, Thomas; Englezou, Pavlos; Suter, Rolf; Ruggli, Nicolas (2014). Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines, 2(4), pp. 735-754. MDPI 10.3390/vaccines2040735
Bolz, Miriam; Ruggli, Nicolas; Ruf, Marie-Thérèse; Ricklin, Meret E; Zimmer, Gert; Pluschke, Gerd (2014). Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. PLoS neglected tropical diseases, 8(7), e2968. Public Library of Science 10.1371/journal.pntd.0002968
Gottipati, Keerthi; Acholi, Sudheer; Ruggli, Nicolas; Choi, Kyung H (2014). Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Virology, 452-453, pp. 303-309. Academic Press 10.1016/j.virol.2014.01.026
McCullough, Kenneth C; Bassi, Isabelle; Milona, Panagiota; Suter, Rolf; Thomann-Harwood, Lisa; Englezou, Pavlos; Demoulins, Thomas; Ruggli, Nicolas (2014). Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo. Molecular Therapy - Nucleic Acids, 3(7), e173. Nature Publishing Group 10.1038/mtna.2014.24
Tamura, Tomokazu; Nagashima, Naofumi; Ruggli, Nicolas; Summerfield, Artur; Kida, Hiroshi; Sakoda, Yoshihiro (2014). Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites. Veterinary research, 45(1), p. 47. Biomed Central 10.1186/1297-9716-45-47
Leifer, Immanuel; Ruggli, Nicolas; Blome, Sandra (2013). Approaches to define the viral genetic basis of classical swine fever virus virulence. Virology, 438(2), pp. 51-55. Academic Press 10.1016/j.virol.2013.01.013
Frey, Caroline; Bauhofer, Oliver; Ruggli, Nicolas; Summerfield, Artur; Hofmann, Martin A; Tratschin, Jon-Duri (2006). Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application. Veterinary research, 37(5), pp. 655-670. Editions scientifiques Elsevier 10.1051/vetres:2006028
