The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Patterson, Andrew D.; Lanz, Christian; Gonzalez, Frank J.; Idle, Jeffrey (2009). The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrometry Reviews, 29(3), pp. 503-521. New York, N.Y.: Wiley 10.1002/mas.20272

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Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose-response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High-Throughput Minimally Invasive Radiation Biodosimetry was established to develop field-deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and potential nuclear disasters, discuss the important contributions the field of mass spectrometry has made to the field of radiation metabolomics, and summarize current discovery efforts to use mass spectrometry-based metabolomics to identify dose-responsive urinary constituents, and ultimately to build and deploy a noninvasive high-throughput biodosimeter.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
UniBE Contributor:	Lanz, Christian, Idle, Jeffrey
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0277-7037
Publisher:	Wiley
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:07
Last Modified:	05 Dec 2022 14:00
Publisher DOI:	10.1002/mas.20272
PubMed ID:	19890938
Web of Science ID:	000277326100005
URI:	https://boris.unibe.ch/id/eprint/77 (FactScience: 195177)