The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Patterson, Andrew D.; Lanz, Christian; Gonzalez, Frank J.; Idle, Jeffrey (2009). The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrometry Reviews, 29(3), pp. 503-521. New York, N.Y.: Wiley 10.1002/mas.20272

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Radiation metabolomics can be defined as the global profiling of biological fluids to uncover latent, endogenous small molecules whose concentrations change in a dose-response manner following exposure to ionizing radiation. In response to the potential threat of nuclear or radiological terrorism, the Center for High-Throughput Minimally Invasive Radiation Biodosimetry was established to develop field-deployable biodosimeters based, in part, on rapid analysis by mass spectrometry of readily and easily obtainable biofluids. In this review, we briefly summarize radiation biology and key events related to actual and potential nuclear disasters, discuss the important contributions the field of mass spectrometry has made to the field of radiation metabolomics, and summarize current discovery efforts to use mass spectrometry-based metabolomics to identify dose-responsive urinary constituents, and ultimately to build and deploy a noninvasive high-throughput biodosimeter.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Lanz, Christian and Idle, Jeffrey

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0277-7037

Publisher:

Wiley

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

03 May 2014 01:38

Publisher DOI:

10.1002/mas.20272

PubMed ID:

19890938

Web of Science ID:

000277326100005

URI:

https://boris.unibe.ch/id/eprint/77 (FactScience: 195177)

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