Calcium Disorders in the Emergency Department: Independent Risk Factors for Mortality.

Sauter, Thomas; Lindner, Gregor; Ahmad, Sufian; Leichtle, Alexander Benedikt; Fiedler, Martin; Exadaktylos, Aristomenis; Haider, Dominik (2015). Calcium Disorders in the Emergency Department: Independent Risk Factors for Mortality. PLoS ONE, 10(7), e0132788. Public Library of Science 10.1371/journal.pone.0132788

[img]
Preview
Text
pone.0132788.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (360kB) | Preview

BACKGROUND Calcium disorders are common in both intensive care units and in patients with chronic kidney disease and are associated with increased morbidity and mortality. It is unknown whether calcium abnormalities in unselected emergency department admissions have an impact on in-hospital mortality. METHODS This cross-sectional analysis included all admissions to the Emergency Department at the Inselspital Bern, Switzerland from 2010 to 2011. For hyper- and hypocalcaemic patients with a Mann-Whitney U-test, the differences between subgroups divided by age, length of hospital stay, creatinine, sodium, chloride, phosphate, potassium and magnesium were compared. Associations between calcium disorders and 28-day in-hospital mortality were assessed using the Cox proportional hazard regression model. RESULTS 8,270 patients with calcium measurements were included in our study. Overall 264 (3.2%) patients died. 150 patients (6.13%) with hypocalcaemia and 7 patients with hypercalcaemia (6.19%) died, in contrast to 104 normocalcaemic patients (1.82%). In univariate analysis, calcium serum levels were associated with sex, mortality and pre-existing diuretic therapy (all p<0.05). In multivariate Cox regression analysis, hypocalcaemia and hypercalcaemia were independent risk factors for mortality (HR 2.00 and HR 1.88, respectively; both p<0.01). CONCLUSION Both hypocalcaemia and hypercalcaemia are associated with increased 28-day in-hospital mortality in unselected emergency department admissions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Sauter, Thomas; Lindner, Gregor; Ahmad, Sufian; Leichtle, Alexander Benedikt; Fiedler, Martin; Exadaktylos, Aristomenis and Haider, Dominik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Marie-Christine Müller

Date Deposited:

22 Feb 2016 17:18

Last Modified:

10 Mar 2016 10:02

Publisher DOI:

10.1371/journal.pone.0132788

PubMed ID:

26172117

BORIS DOI:

10.7892/boris.77159

URI:

https://boris.unibe.ch/id/eprint/77159

Actions (login required)

Edit item Edit item
Provide Feedback