Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis

Patsenker, Eleonora; Schneider, Vreni; Ledermann, Monika; Saegesser, Hans; Dorn, Christoph; Hellerbrand, Claus; Stickel, Felix (2011). Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis. Journal of hepatology, 55(2), pp. 388-98. Amsterdam: Elsevier 10.1016/j.jhep.2010.10.044

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Recurrence of chronic hepatitis C and progressive fibrosis in liver transplants is frequent and impairs both graft and patient survival. Whether or not the choice of immunosuppression affects progression of fibrosis remains unclear. The aim of the present study was to compare the potential of the commonly used immunosuppressants to halt experimental liver fibrosis progression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Stickel, Felix

ISSN:

0168-8278

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

06 Dec 2013 13:28

Publisher DOI:

10.1016/j.jhep.2010.10.044

PubMed ID:

21168455

Web of Science ID:

000293429100022

URI:

https://boris.unibe.ch/id/eprint/7731 (FactScience: 213057)

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