Clinical Diagnosis and Staging of Intrahepatic Cholangiocarcinoma.

Bartella, Isabel; Dufour, Jean-François (2015). Clinical Diagnosis and Staging of Intrahepatic Cholangiocarcinoma. Journal of gastrointestinal and liver diseases, 24(4), pp. 481-489. Medical University Press 10.15403/jgld.2014.1121.244.chl

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Intrahepatic cholangiocarcinomas are the second most common primary liver malignancies with an increasing incidence over the past decades. Due to a lack of early symptoms and their aggressive oncobiological behavior, the diagnostic approach is challenging and the outcome remains unsatisfactory with a poor prognosis. Thus, a consistent staging system for a comparison between different therapeutic approaches is needed, but independent predictors for worse survival are still controversial. Currently, four different staging systems are primarily used, which differ in the way they determine the 'T' category. Furthermore, different nomograms and prognostic models have been recently proposed and may be helpful in providing additional information for predicting the prognosis and therefore be helpful in approaching an adequate treatment strategy. This review will discuss the diagnostic approach to intrahepatic cholangiocarcinoma as well as compare and contrast the most current staging systems and prognostic models.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1841-8724

Publisher:

Medical University Press

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

11 Apr 2016 16:12

Last Modified:

12 Sep 2017 06:32

Publisher DOI:

10.15403/jgld.2014.1121.244.chl

PubMed ID:

26697575

BORIS DOI:

10.7892/boris.77712

URI:

https://boris.unibe.ch/id/eprint/77712

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