The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment.

Margini, Cristina; Dufour, Jean-François (2016). The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment. Liver international, 36(3), pp. 317-324. Blackwell Munksgaard 10.1111/liv.13031

[img] Text
The story of HCC in NAFLD from epidemiology, across pathogenesis, to prevention and treatment..pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (278kB) | Request a copy

BACKGROUND & AIMS Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. An increasing number of reports describe HCC in the setting of obesity and diabetes, two major risk factors for non-alcoholic fatty liver disease (NAFLD). The increasing incidence of these conditions and the emerging evidence of HCC in non-cirrhotic NAFLD prioritize a better understanding of NAFLD-related HCC epidemiology and pathogenesis in order to target screening policies and develop preventive-therapeutic strategies. In this review, we focus on the epidemiological impact of this condition, suggesting a possible link between HCC in cryptogenic cirrhosis and NAFLD. Furthermore, we analyse the suggested pathogenic mechanisms and the possible preventive-therapeutic strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1478-3223

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

12 Apr 2016 11:42

Last Modified:

16 Sep 2017 16:06

Publisher DOI:

10.1111/liv.13031

PubMed ID:

26601627

Uncontrolled Keywords:

HCC; NAFLD; diabetes; obesity

BORIS DOI:

10.7892/boris.77715

URI:

https://boris.unibe.ch/id/eprint/77715

Actions (login required)

Edit item Edit item
Provide Feedback