N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo

Angst, Eliane; Dawson, David W; Stroka, Deborah; Gloor, Beat; Park, Jenny; Candinas, Daniel; Reber, Howard A; Hines, O Joe; Eibl, Guido (2011). N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery, 149(5), pp. 614-24. New York, N.Y.: Elsevier 10.1016/j.surg.2010.11.002

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The role of N-myc downstream regulated gene-1 (NDRG1) in cancer has recently gained interest, as potential regulator of cell death and tumor suppressor. Although its normal function in the pancreas is largely unknown, loss of NDRG1 expression is associated with a more aggressive tumor phenotype and poor outcome in pancreatic cancer patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Angst, Eliane; Keogh-Stroka, Deborah M.; Gloor, Beat and Candinas, Daniel

ISSN:

0039-6060

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

17 Mar 2015 19:09

Publisher DOI:

10.1016/j.surg.2010.11.002

PubMed ID:

21236457

Web of Science ID:

000289930700004

URI:

https://boris.unibe.ch/id/eprint/780 (FactScience: 200832)

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