Internal bacterial colonization of implants: association with peri-implant bone loss

Jervøe-Storm, Pia-Merete; Jepsen, Søren; Jöhren, Peter; Mericske, Regina; Enkling, Norbert (2015). Internal bacterial colonization of implants: association with peri-implant bone loss. Clinical oral implants research, 26(8), pp. 957-963. Wiley-Blackwell 10.1111/clr.12421

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OBJECTIVES The aim of the present longitudinal study was to investigate bacterial colonization of the internal implant cavity and to evaluate a possible association with peri-implant bone loss. METHODS A total of 264 paper point samples were harvested from the intra-implant cavity of 66 implants in 26 patients immediately following implant insertion and after 3, 4, and 12 months. Samples were evaluated for Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, and Tannerella forsythia as well as total bacterial counts by real-time PCR. Bone loss was evaluated on standardized radiographs up to 25 months after implant insertion. For the statistical analysis of the data, mixed effects models were fitted. RESULTS There was an increase in the frequency of detection as well as in the mean counts of the selected bacteria over time. The evaluation of the target bacteria revealed a significant association of Pr. intermedia at 4 and 12 months with peri-implant bone loss at 25 months (4 months: P = 0.009; 12 months: P = 0.021). CONCLUSIONS The present study could demonstrate a progressive colonization by periodontopathogenic bacteria in the internal cavities of two-piece implants. The results suggest that internal colonization with Pr. intermedia was associated with peri-implant bone loss.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Reconstructive Dentistry and Gerodontology

UniBE Contributor:

Mericske, Regina and Enkling, Norbert


600 Technology > 610 Medicine & health








Eveline Carmen Schuler

Date Deposited:

29 Mar 2016 11:22

Last Modified:

11 Sep 2017 19:06

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

bacterial colonization, bone loss, dental implant, eriodontal pathogens, real-time PCR




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