Accuracy of continuous glucose monitoring during differing exercise conditions.

Bally, Lia; Züger, Thomas; Pasi, Nicola; Ciller, Carlos; Paganini, Daniela; Stettler, Christoph (2016). Accuracy of continuous glucose monitoring during differing exercise conditions. Diabetes research and clinical practice, 112, pp. 1-5. Elsevier 10.1016/j.diabres.2015.11.012

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AIM Depending on intensity, exercise may induce a strong hormonal and metabolic response, including acid-base imbalances and changes in microcirculation, potentially interfering with the accuracy of continuous glucose monitoring (CGM). The present study aimed at comparing the accuracy of the Dexcom G4 Platinum (DG4P) CGM during continuous moderate and intermittent high-intensity exercise (IHE) in adults with type 1 diabetes (T1DM). METHODS Ten male individuals with well-controlled T1DM (HbA1c 7.0±0.6% [54±6mmol/mol]) inserted the DG4P sensor 2 days prior to a 90min cycling session (50% VO2peak) either with (IHE) or without (CONT) a 10s all-out sprint every 10min. Venous blood samples for reference glucose measurement were drawn every 10min and euglycemia (target 7mmol/l) was maintained using an oral glucose solution. Additionally, lactate and venous blood gas variables were determined. RESULTS Mean reference blood glucose was 7.6±0.2mmol/l during IHE and 6.7±0.2mmol/l during CONT (p<0.001). IHE resulted in significantly higher levels of lactate (7.3±0.5mmol/l vs. 2.6±0.3mmol/l, p<0.001), while pH values were significantly lower in the IHE group (7.27 vs. 7.38, p=0.001). Mean absolute relative difference (MARD) was 13.3±2.2% for IHE and 13.6±2.8% for CONT suggesting comparable accuracy (p=0.90). Using Clarke Error Grid Analysis, 100% of CGM values during both IHE and CONT were in zones A and B (IHE: 77% and 23%; CONT: 78% and 22%). CONCLUSIONS The present study revealed good and comparable accuracy of the DG4P CGM system during intermittent high intensity and continuous moderate intensity exercise, despite marked differences in metabolic conditions. This corroborates the clinical robustness of CGM under differing exercise conditions. CLINICAL TRIAL REGISTRATION NUMBER ClinicalTrials.gov NCT02068638.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Ophthalmic Technology Lab
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bally, Lia; Züger, Thomas; Ciller, Carlos and Stettler, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0168-8227

Publisher:

Elsevier

Language:

English

Submitter:

Markus Laimer

Date Deposited:

20 Apr 2016 09:25

Last Modified:

23 Jan 2017 10:20

Publisher DOI:

10.1016/j.diabres.2015.11.012

PubMed ID:

26739116

Uncontrolled Keywords:

Accuracy, Continuous glucose monitoring, Continuous moderate intensity, exercise, Intermittent high-intensity exercise, Type 1 diabetes

BORIS DOI:

10.7892/boris.78550

URI:

https://boris.unibe.ch/id/eprint/78550

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