Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

Béguelin, Charles Antoine; Vázquez, Miriam; Bertschi, Manuel; Yerly, S; de Jong, Denise; Gutbrod, Klemens; Rauch, Andri; Cusini, Alexia (2015). Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1. Open Forum Infectious Diseases, 3(1), ofv210. Oxford University Press 10.1093/ofid/ofv210

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In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.

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