Romeo, Valentina; Schümperli, Daniel (2016). Cycling in the nucleus: regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes. Current opinion in cell biology, 40, pp. 23-31. Elsevier 10.1016/j.ceb.2016.01.015
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The histones which pack new DNA during the S phase of animal cells are made from mRNAs that are cleaved at their 3' end but not polyadenylated. Some of the factors used in this reaction are unique to it while others are shared with the polyadenylation process that generates all other mRNAs. Recent work has begun to shed light on how the cell manages the assignment of these common components to the two 3' processing systems, and how it achieves their cell cycle-regulation and recruitment to the histone pre-mRNA. Moreover, recent and older findings reveal multiple connections between the nuclear organization of histone genes, their transcription and 3' end processing as well as the control of cell proliferation.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology > RNA 08 Faculty of Science > Department of Biology > Institute of Cell Biology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Romeo, Valentina, Schümperli, Daniel |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0955-0674 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Daniel Schümperli |
Date Deposited: |
10 Mar 2016 16:48 |
Last Modified: |
05 Dec 2022 14:53 |
Publisher DOI: |
10.1016/j.ceb.2016.01.015 |
PubMed ID: |
26895140 |
BORIS DOI: |
10.7892/boris.78643 |
URI: |
https://boris.unibe.ch/id/eprint/78643 |
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