Combination therapy for multidrug-resistant cytomegalovirus disease

Stuehler, C.; Stüssi, G.; Halter, J.; Nowakowska, J.; Schibli, A.; Battegay, M.; Dirks, J.; Passweg, J.; Heim, D.; Rovó, Alicia; Kalberer, C.; Bucher, C.; Weisser, M.; Dumoulin, A.; Hirsch, H.H.; Khanna, N. (2015). Combination therapy for multidrug-resistant cytomegalovirus disease. Transplant infectious disease, 17(5), pp. 751-755. Wiley 10.1111/tid.12435

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Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Rovó, Alicia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1398-2273

Publisher:

Wiley

Language:

English

Submitter:

Verena Zwahlen

Date Deposited:

24 Mar 2016 10:57

Last Modified:

24 Mar 2016 10:57

Publisher DOI:

10.1111/tid.12435

PubMed ID:

26432076

BORIS DOI:

10.7892/boris.78706

URI:

https://boris.unibe.ch/id/eprint/78706

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