Combination therapy for multidrug-resistant cytomegalovirus disease

Stuehler, C.; Stüssi, G.; Halter, J.; Nowakowska, J.; Schibli, A.; Battegay, M.; Dirks, J.; Passweg, J.; Heim, D.; Rovó, Alicia; Kalberer, C.; Bucher, C.; Weisser, M.; Dumoulin, A.; Hirsch, H.H.; Khanna, N. (2015). Combination therapy for multidrug-resistant cytomegalovirus disease. Transplant infectious disease, 17(5), pp. 751-755. Wiley 10.1111/tid.12435

Text AR_tid12435.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (371kB) | Request a copy

Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.

© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Interest & Impact

Downloads

5 since deposited on 24 Mar 2016
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item