Stuehler, C.; Stüssi, G.; Halter, J.; Nowakowska, J.; Schibli, A.; Battegay, M.; Dirks, J.; Passweg, J.; Heim, D.; Rovó, Alicia; Kalberer, C.; Bucher, C.; Weisser, M.; Dumoulin, A.; Hirsch, H.H.; Khanna, N. (2015). Combination therapy for multidrug-resistant cytomegalovirus disease. Transplant infectious disease, 17(5), pp. 751-755. Wiley 10.1111/tid.12435
Text
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Multidrug-resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV-seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV-seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re-transplantation from a CMV-seropositive donor supported by adoptive transfer of pp65-specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Rovó, Alicia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1398-2273 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Verena Zwahlen |
Date Deposited: |
24 Mar 2016 10:57 |
Last Modified: |
05 Dec 2022 14:53 |
Publisher DOI: |
10.1111/tid.12435 |
PubMed ID: |
26432076 |
BORIS DOI: |
10.7892/boris.78706 |
URI: |
https://boris.unibe.ch/id/eprint/78706 |