15 years of microstate research in schizophrenia - Where are we? A meta-analysis

Rieger, Kathryn; Diaz, Laura; Bänninger, Anja; König, Thomas (2016). 15 years of microstate research in schizophrenia - Where are we? A meta-analysis. Frontiers in psychiatry, 7(22), pp. 1-7. Frontiers 10.3389/fpsyt.2016.00022

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Schizophrenia patients show abnormalities in a broad range of task demands. Therefore, an explanation common to all these abnormalities has to be sought independently of any particular task, ideally in the brain dynamics before a task takes place or during resting state. For the neurobiological investigation of such baseline states, EEG microstate analysis is particularly well suited, because it identifies subsecond global states of stable connectivity patterns directly related to the recruitment of different types of information processing modes (e.g., integration of top-down and bottom-up information). Meanwhile, there is an accumulation of evidence that particular microstate networks are selectively affected in schizophrenia. To obtain an overall estimate of the effect size of these microstate abnormalities, we present a systematic meta-analysis over all studies available to date relating EEG microstates to schizophrenia. Results showed medium size effects for two classes of microstates, namely, a class labeled C that was found to be more frequent in schizophrenia and a class labeled D that was found to be shortened. These abnormalities may correspond to core symptoms of schizophrenia, e.g., insufficient reality testing and self-monitoring as during auditory verbal hallucinations. As interventional studies have shown that these microstate features may be systematically affected using antipsychotic drugs or neurofeedback interventions, these findings may help introducing novel diagnostic and treatment options.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
07 Faculty of Human Sciences > Institute of Psychology > Developmental Psychology

Graduate School:

Swiss Graduate School for Cognition, Learning and Memory (SGS-CLM)
Graduate School for Health Sciences (GHS)

UniBE Contributor:

Rieger, Kathryn; Diaz, Laura; Bänninger, Anja and König, Thomas

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1664-0640

Publisher:

Frontiers

Language:

English

Submitter:

Kathryn Heri

Date Deposited:

02 Mar 2016 10:44

Last Modified:

15 Sep 2017 08:05

Publisher DOI:

10.3389/fpsyt.2016.00022

PubMed ID:

26955358

BORIS DOI:

10.7892/boris.78875

URI:

https://boris.unibe.ch/id/eprint/78875

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