Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death.

Abriel, Hugues; Rougier, Jean-Sébastien; Jalife, José (2015). Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death. Circulation research, 116(12), pp. 1971-1988. Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.116.305017

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The movement of ions across specific channels embedded on the membrane of individual cardiomyocytes is crucial for the generation and propagation of the cardiac electric impulse. Emerging evidence over the past 20 years strongly suggests that the normal electric function of the heart is the result of dynamic interactions of membrane ion channels working in an orchestrated fashion as part of complex molecular networks. Such networks work together with exquisite temporal precision to generate each action potential and contraction. Macromolecular complexes play crucial roles in transcription, translation, oligomerization, trafficking, membrane retention, glycosylation, post-translational modification, turnover, function, and degradation of all cardiac ion channels known to date. In addition, the accurate timing of each cardiac beat and contraction demands, a comparable precision on the assembly and organizations of sodium, calcium, and potassium channel complexes within specific subcellular microdomains, where physical proximity allows for prompt and efficient interaction. This review article, part of the Compendium on Sudden Cardiac Death, discusses the major issues related to the role of ion channel macromolecular assemblies in normal cardiac electric function and the mechanisms of arrhythmias leading to sudden cardiac death. It provides an idea of how these issues are being addressed in the laboratory and in the clinic, which important questions remain unanswered, and what future research will be needed to improve knowledge and advance therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten

UniBE Contributor:

Abriel, Hugues and Rougier, Jean-Sébastien

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0009-7330

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Verena de Serra Frazao-Bill

Date Deposited:

13 Apr 2016 11:43

Last Modified:

16 Sep 2017 17:21

Publisher DOI:

10.1161/CIRCRESAHA.116.305017

PubMed ID:

26044251

Uncontrolled Keywords:

arrhythmias, cardiac death, sudden, cardiac ion channels multiprotein complexes

BORIS DOI:

10.7892/boris.80626

URI:

https://boris.unibe.ch/id/eprint/80626

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