INI1 (BAF 47) immunohistochemistry is an essential diagnostic tool for children with hepatic tumors and low alpha fetoprotein

Al Nassan, Anwar; Sughayer, Maher; Matalka, Ismail; Ghandour, Khalil; Masarweh, Main; Zimmermann, Arthur; Sultan, Iyad (2010). INI1 (BAF 47) immunohistochemistry is an essential diagnostic tool for children with hepatic tumors and low alpha fetoprotein. Journal of pediatric hematology, oncology, 32(2), e79-81. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MPH.0b013e3181b79613

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Malignant rhabdoid tumor (MRT) of the liver is a rare malignancy with grave prognosis. This entity should be considered in the differential diagnosis of any aggressive liver tumor with low levels of alpha fetoprotein. We report 2 cases of hepatic MRT presenting in infancy. In these 2 cases, we show that loss of INI1 facilitates making the correct diagnosis of primary hepatic MRT utilizing BAF 47 (INI1 gene product) immunostains. Difficulty encountered in making this rare diagnosis, including the need for repeated biopsies, can be avoided if MRT is considered in the differential diagnosis early on and BAF 47 immunohistochemistry is ordered.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Zimmermann, Arthur

ISSN:

1077-4114

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

17 Mar 2015 19:09

Publisher DOI:

10.1097/MPH.0b013e3181b79613

PubMed ID:

20048688

Web of Science ID:

000275559800036

URI:

https://boris.unibe.ch/id/eprint/807 (FactScience: 200882)

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