Importance of cholesterol and cholesterol transporters in the placental trophoblast during pregnancy

Jain, Arjun; Albrecht, Christiane (2015). Importance of cholesterol and cholesterol transporters in the placental trophoblast during pregnancy. In: Duttaroy, Asim K.; Basak, Sanjay (eds.) Human Placental Trophoblasts: Impact of Maternal Nutrition (pp. 129-144). CRC Press

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Membrane transporters are essential during pregnancy, being a core component of the exchange of nutrients, gases, and metabolic products between the mother and the developing fetus. Important compounds to be transported include vitamins and minerals, amino acids, glucose, as well as cholesterol. Cholesterol transport across the plasma membrane is mediated mainly by members of the ATP-binding cassette (ABC) transporter family. Cholesterol is present in every cell of the body, where it helps maintain the integrity of cell membranes and also plays an important role in cell signaling events. Cholesterol also acts as a precursor for the biosynthesis of steroids that include sex hormones, glucocorticoids, mineralcorticoids, as well as bile acids and oxysterols. Cholesterol transport is therefore crucial for a host of different physiological processes. The following chapter addresses the involvement and importance of ABC transporters in these different processes. The critical role that ABC transporters Play for a successful pregnancy outcome is highlighted by pathological processes that result malfunction of cholesterol transport during pregnancy. Avenues of future research are also described, which may help to further delineate the function and mechanism of action of ABC transporters.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Jain, Arjun and Albrecht, Christiane

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISBN:

9781482254280

Publisher:

CRC Press

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

14 Apr 2016 09:00

Last Modified:

14 Apr 2016 09:00

Uncontrolled Keywords:

Placenta, Trophoblast, Cholesterol, Membrane Transporters, ABCA1, Signaling pathways, Angiogenesis

URI:

https://boris.unibe.ch/id/eprint/80979

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