The major central endocannabinoid directly acts at GABA(A) receptors

Sigel, Erwin; Baur, Roland; Rácz, Ildiko; Marazzi, Janine; Smart, Trevor G; Zimmer, Andreas; Gertsch, Jürg (2011). The major central endocannabinoid directly acts at GABA(A) receptors. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 108(44), pp. 18150-5. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.1113444108

Full text not available from this repository. (Request a copy)

GABA(A) receptors are the major ionotropic inhibitory neurotransmitter receptors. The endocannabinoid system is a lipid signaling network that modulates different brain functions. Here we show a direct molecular interaction between the two systems. The endocannabinoid 2-arachidonoyl glycerol (2-AG) potentiates GABA(A) receptors at low concentrations of GABA. Two residues of the receptor located in the transmembrane segment M4 of β(2) confer 2-AG binding. 2-AG acts in a superadditive fashion with the neurosteroid 3α, 21-dihydroxy-5α-pregnan-20-one (THDOC) and modulates δ-subunit-containing receptors, known to be located extrasynaptically and to respond to neurosteroids. 2-AG inhibits motility in CB(1)/CB(2) cannabinoid receptor double-KO, whereas β(2)-KO mice show hypermotility. The identification of a functional binding site for 2-AG in the GABA(A) receptor may have far-reaching consequences for the study of locomotion and sedation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Sigel, Erwin; Baur, Roland; Marazzi, Janine and Gertsch, Jürg

ISSN:

0027-8424

Publisher:

National Academy of Sciences NAS

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

06 Dec 2013 13:29

Publisher DOI:

10.1073/pnas.1113444108

PubMed ID:

22025726

Web of Science ID:

000296373400057

URI:

https://boris.unibe.ch/id/eprint/8151 (FactScience: 213639)

Actions (login required)

Edit item Edit item
Provide Feedback