Clonality and Antimicrobial Susceptibility of Burkholderia cepacia complex Isolates Collected from Cystic Fibrosis Patients during 1998-2013 in Bern, Switzerland.

Lupo, Agnese; Isis, Enver; Tinguely, Regula; Endimiani, Andrea (2015). Clonality and Antimicrobial Susceptibility of Burkholderia cepacia complex Isolates Collected from Cystic Fibrosis Patients during 1998-2013 in Bern, Switzerland. The new microbiologica, 38(2), pp. 281-288. Edizioni Medico Scientifiche

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For the first time, we analyzed the clonality and susceptibility of Burkholderia cepacia complex isolates (n=55) collected during 1998-2013 from 44 Swiss cystic fibrosis (CF)-patients. B. cenocepacia (n=28) and B. multivorans (n=14) were mainly of sequence type (ST) 833 and ST874, respectively; B. contaminans isolates were of ST102. Overall, the following MIC50/90s (mg/l) were obtained: piperacillin/tazobactam (≤ 4/≥ 128), ticarcillin/clavulanate (≥ 256/≥256), ceftazidime (2/≥ 32), aztreonam (16/≥ 32), meropenem (2/8), tobramycin (8/≥ 16), minocycline (≤ 1/16), levofloxacin (≤ 0.5/≥ 16), and trimethoprim/sulfamethoxazole (≤ 0.5/4). This is the first survey providing information on the clonality of Bcc detected in Switzerland. Species identification and antimicrobial susceptibility tests should always be routinely performed to adapt more targeted therapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Lupo, Agnese; Isis, Enver; Tinguely, Regula and Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1121-7138

Publisher:

Edizioni Medico Scientifiche

Language:

English

Submitter:

Andrea Endimiani

Date Deposited:

02 May 2016 10:58

Last Modified:

02 May 2016 10:58

PubMed ID:

25938755

Uncontrolled Keywords:

Bcc, Burkholderia, Clonality, Cystic fibrosis, MIC, MLST

BORIS DOI:

10.7892/boris.81553

URI:

https://boris.unibe.ch/id/eprint/81553

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