Schiess, Raphael; Gertsch, Jürg; Schweizer, W Bernd; Altmann, Karl-Heinz (2011). Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants. Organic letters, 13(6), pp. 1436-9. Washington, D.C.: American Chemical Society 10.1021/ol200114k
Full text not available from this repository.A general strategy has been devised for the stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants thereof, which relies on late stage introduction of the heterocycle through Wittig olefination of ketone 14. Formation of the macrocycle was achieved through RCM-based ring closure and introduction of the cyclopropane moiety involved a highly selective Charette cyclopropanation of allylic alcohol 7.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Gertsch, Jürg |
ISSN: |
1523-7060 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:23 |
Last Modified: |
05 Dec 2022 14:06 |
Publisher DOI: |
10.1021/ol200114k |
PubMed ID: |
21338105 |
Web of Science ID: |
000288148800044 |
URI: |
https://boris.unibe.ch/id/eprint/8162 (FactScience: 213650) |
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