Brinkmann, J; Jagannathan, Vidhya; Drögemüller, Cord; Rieder, S; Leeb, Tosso; Thaller, G; Tetens, J (2016). Genetic variability of the equine casein genes. Journal of dairy science, 99(7), pp. 5486-5497. American Dairy Science Association 10.3168/jds.2015-10652
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The casein genes are known to be highly variable in typical dairy species, such as cattle and goat, but the knowledge about equine casein genes is limited. Nevertheless, mare milk production and consumption is gaining importance because of its high nutritive value, use in naturopathy, and hypoallergenic properties with respect to cow milk protein allergies. In the current study, the open reading frames of the 4 casein genes CSN1S1 (αS1-casein), CSN2 (β-casein), CSN1S2 (αS2-casein), and CSN3 (κ-casein) were resequenced in 253 horses of 14 breeds. The analysis revealed 21 nonsynonymous nucleotide exchanges, as well as 11 synonymous nucleotide exchanges, leading to a total of 31 putative protein isoforms predicted at the DNA level, 26 of which considered novel. Although the majority of the alleles need to be confirmed at the transcript and protein level, a preliminary nomenclature was established for the equine casein alleles.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Jagannathan, Vidya, Drögemüller, Cord, Leeb, Tosso |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture |
ISSN: |
0022-0302 |
Publisher: |
American Dairy Science Association |
Language: |
English |
Submitter: |
Cord Drögemüller |
Date Deposited: |
01 Jul 2016 16:34 |
Last Modified: |
05 Dec 2022 14:56 |
Publisher DOI: |
10.3168/jds.2015-10652 |
PubMed ID: |
27108172 |
Uncontrolled Keywords: |
caseins; genetic variability; isoforms; mare milk |
BORIS DOI: |
10.7892/boris.82605 |
URI: |
https://boris.unibe.ch/id/eprint/82605 |