Banz, Yara; Hess, Otto M; Meier, Pascal; Korchagina, Elena Y; Gordeeva, Elena A; Robson, Simon C; Gajanayake, Thusitha; Csizmadia, Eva; Mettler, Daniel; Haeberli, André; Bovin, Nicolai V; Rieben, Robert (2012). Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs. Cardiology, 121(1), pp. 59-70. Basel: Karger 10.1159/000336485
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Intracoronary administration of glycosaminoglycan analogs, including the complement inhibitor dextran sulfate, attenuates myocardial ischemia/reperfusion injury (I/R injury). However, dextran sulfate has a distinct anticoagulatory effect, possibly limiting its use in specific situations in vivo. We therefore developed multimeric tyrosine sulfate (sTyr-PAA), a novel, minimally anticoagulatory, fully synthetic non-carbohydrate-containing polyacrylamide conjugate, for in vivo testing in an acute closed-chest porcine model of acute myocardial infarction.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe |
UniBE Contributor: |
Banz Wälti, Yara Sarah, Rieben, Robert |
ISSN: |
0008-6312 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:24 |
Last Modified: |
25 May 2023 08:42 |
Publisher DOI: |
10.1159/000336485 |
PubMed ID: |
22398380 |
Web of Science ID: |
000301687700010 |
BORIS DOI: |
10.48350/8580 |
URI: |
https://boris.unibe.ch/id/eprint/8580 (FactScience: 214169) |
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