Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs

Banz, Yara; Hess, Otto M; Meier, Pascal; Korchagina, Elena Y; Gordeeva, Elena A; Robson, Simon C; Gajanayake, Thusitha; Csizmadia, Eva; Mettler, Daniel; Haeberli, André; Bovin, Nicolai V; Rieben, Robert (2012). Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs. Cardiology, 121(1), pp. 59-70. Basel: Karger 10.1159/000336485

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Intracoronary administration of glycosaminoglycan analogs, including the complement inhibitor dextran sulfate, attenuates myocardial ischemia/reperfusion injury (I/R injury). However, dextran sulfate has a distinct anticoagulatory effect, possibly limiting its use in specific situations in vivo. We therefore developed multimeric tyrosine sulfate (sTyr-PAA), a novel, minimally anticoagulatory, fully synthetic non-carbohydrate-containing polyacrylamide conjugate, for in vivo testing in an acute closed-chest porcine model of acute myocardial infarction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe

UniBE Contributor:

Banz Wälti, Yara and Rieben, Robert

ISSN:

0008-6312

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

17 Mar 2015 21:05

Publisher DOI:

10.1159/000336485

PubMed ID:

22398380

Web of Science ID:

000301687700010

URI:

https://boris.unibe.ch/id/eprint/8580 (FactScience: 214169)

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