Eosinophilic bioactivities in severe asthma

Carr, Tara F; Berdnikovs, Sergejs; Simon, Hans-Uwe; Bochner, Bruce S; Rosenwasser, Lanny J (2016). Eosinophilic bioactivities in severe asthma. World Allergy Organization journal, 9, p. 21. BioMed Central 10.1186/s40413-016-0112-5

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Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and airways despite guidelines-based treatment. This review details eosinophil effector mechanisms, surface markers, and clinical outcomes associated with eosinophilia and asthma severity. There is interest in the potential of eosinophils or their products to predict treatment response with biotherapeutics and their usefulness as biomarkers. This is important as monoclonal antibodies are targeting cytokines and eosinophils in different lung environments for treating severe asthma. Identifying disease state-specific eosinophil biomarkers would help to refine these strategies and choose likely responders to biotherapeutics.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1939-4551

Publisher:

BioMed Central

Language:

English

Submitter:

Debora Scherrer

Date Deposited:

13 Sep 2016 13:20

Last Modified:

28 Nov 2020 02:27

Publisher DOI:

10.1186/s40413-016-0112-5

PubMed ID:

27386041

Uncontrolled Keywords:

Bioactivities; Biotherapeutics; Eosinophilia; Eosinophils; Severe asthma

BORIS DOI:

10.7892/boris.87508

URI:

https://boris.unibe.ch/id/eprint/87508

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