Colon cancer cells produce immunoregulatory glucocorticoids

Sidler, Daniel; Renzulli, Pietro; Schnoz, Christina; Berger, Barbara; Schneider-Jakob, Sabine; Flück, Christa; Inderbitzin, Daniel; Corazza, Nadia; Candinas, Daniel; Brunner, Thomas (2012). Colon cancer cells produce immunoregulatory glucocorticoids. Oncoimmunology, 1(4), pp. 529-530. Austin, Tex.: Landes Bioscience

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Expression or release of immunosuppressive molecules may protect tumor cells from the recognition and destruction by the immune system. New findings indicate that colorectal tumors produce immunoregulatory glucocorticoids and thereby suppress immune cell activation. The nuclear receptor LRH-1 plays a critical role in the regulation of colorectal tumor proliferation and glucocorticoid synthesis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Renzulli, Pietro, Flück Pandey, Christa Emma, Inderbitzin, Daniel, Corazza, Nadia, Candinas, Daniel




Landes Bioscience




Anette van Dorland

Date Deposited:

04 Oct 2013 14:25

Last Modified:

02 Mar 2023 23:21

PubMed ID:


URI: (FactScience: 214498)

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