Cell death modulation by intravenous immunoglobulin

von Gunten, Stephan; Simon, Hans-Uwe (2010). Cell death modulation by intravenous immunoglobulin. Journal of clinical immunology, 30 Suppl 1, S24-30. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s10875-010-9411-8

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The induction of cell death in immune cells by naturally occurring antibodies specific for death receptors may present an important antiinflammatory mechanism of intravenous immunoglobulin (IVIG). Conversely, the protection of tissue cells from death receptor-mediated apoptosis by blocking antibodies is thought to contribute to the beneficial effects of IVIG in certain inflammatory disorders such as toxic epidermal necrolysis, also known as Lyell's syndrome. In this review, we focus on recent insights into the role of functional antibodies against Fas, sialic acid-binding immunoglobulin-like lectin (Siglec)-8, and Siglec-9 receptors in IVIG-mediated cell survival or death effects. In addition, we examine a variety of factors in inflammatory disease that may interplay with these cellular events and influence the therapeutic efficacy or potency of IVIG. These involve activation status of the target cell, cytokine microenvironment, pathogenesis and stage of disease, individual genetic determinants, species characteristics, and batch-to-batch variations of IVIG preparations.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

von Gunten, Stephan and Simon, Hans-Uwe

ISSN:

0271-9142

Publisher:

Springer US; http://www.springer-ny.com

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

30 Jul 2020 08:54

Publisher DOI:

10.1007/s10875-010-9411-8

PubMed ID:

20405180

Web of Science ID:

000278622300006

BORIS DOI:

10.7892/boris.886

URI:

https://boris.unibe.ch/id/eprint/886 (FactScience: 201178)

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