Human mast cells express intracellular TRAIL

Berent-Maoz, Beata; Salemi, Souzan; Mankuta, David; Simon, Hans-Uwe; Levi-Schaffer, Francesca (2010). Human mast cells express intracellular TRAIL. Cellular immunology, 262(2), pp. 80-3. San Diego, Calif.: Elsevier 10.1016/j.cellimm.2010.02.003

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Recently we demonstrated that human mast cells (MC) express functional TRAIL death receptors. Here we assessed the expression of TRAIL on both mRNA and protein level in cord blood derived MC (CBMC) and HMC-1. The TRAIL release either spontaneous or induced by LPS, IFN-gamma and IgE-dependent activation, was evaluated as well. The protein location was restricted to the intracellular compartment in CBMC, but not in HMC-1. The intracellular TRAIL was not localized inside the granules. The treatment with IFN-gamma and LPS up-regulated intracellular TRAIL expression in CBMC, but did not induce its release. These in vitro data show that human MC can produce and express intracellular TRAIL whose location could not be altered by different stimuli.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
UniBE Contributor:	Salemi, Souzan, Simon, Hans-Uwe
ISSN:	0008-8749
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:09
Last Modified:	05 Dec 2022 14:00
Publisher DOI:	10.1016/j.cellimm.2010.02.003
PubMed ID:	20189551
Web of Science ID:	000276599100002
URI:	https://boris.unibe.ch/id/eprint/896 (FactScience: 201190)