Patterns and trends of pediatric bloodstream infections: a 7-year surveillance study.

Buetti, Niccolò Ivo Marco-Aurelio; Atkinson, Andrew; Kottanattu, L; Bielicki, J; Marschall, Jonas; Kronenberg, Andreas (2017). Patterns and trends of pediatric bloodstream infections: a 7-year surveillance study. European journal of clinical microbiology & infectious diseases, 36(3), pp. 537-544. Springer 10.1007/s10096-016-2830-6

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We characterize the epidemiology of pediatric bloodstream infections (BSIs) in Switzerland. We analyzed pathogen distribution and resistance patterns in monomicrobial and polymicrobial BSIs in children from 2008 to 2014 using data from the Swiss antibiotic resistance centre (ANRESIS). A confirmatory statistical analysis was performed comparing pathogens and resistance across 20 acute care hospitals. We identified 3,067 bacteremia episodes, of which 1,823 (59 %) were considered true BSI episodes. Overall, S. aureus (16.5 %, 300) was the most frequent pathogen, followed by E. coli (15.1 %, 276), coagulase-negative staphylococci (CoNS, 12.9 %, 235), S. pneumoniae (11.1 %, 202) and non-E. coli Enterobacteriaceae (8.7 %, 159). S. aureus and E. coli showed similar frequencies in all of the variables analyzed (e.g., hospital acquisition, hospital type, medical specialty). The proportion of these microorganisms did not change over time, resistance rates remained low (4.3 % methicillin resistance in S. aureus; 7.3 % third-/fourth-generation cephalosporin resistance in E. coli), and no significant resistance trends were observed. We observed a 50 % increase of CoNS BSIs from 2008 (9.8 %, 27) to 2014 (15.2 %, 46, p value for trend = 0.03). S. pneumoniae decreased from 17.5 % (48) to 6.6 % (20) during that timeframe (p for trend = 0.007). S. aureus and E. coli remained the most significant pathogens among pediatric BSIs in Switzerland, exhibiting low resistance rates. CoNS accounted for a greater proportion of BSIs over time. The decrease in bacteremic pneumococcal infections can likely be attributed to the introduction of the 13-valent conjugate vaccine in 2011.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Buetti, Niccolò Ivo Marco-Aurelio; Atkinson, Andrew; Marschall, Jonas and Kronenberg, Andreas Oskar

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0934-9723

Publisher:

Springer

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

06 Jan 2017 09:42

Last Modified:

16 Feb 2017 11:49

Publisher DOI:

10.1007/s10096-016-2830-6

PubMed ID:

27885442

BORIS DOI:

10.7892/boris.90765

URI:

https://boris.unibe.ch/id/eprint/90765

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