The regulation of inflammation by oxidized phospholipids.

Freigang, Stefan Bernd (2016). The regulation of inflammation by oxidized phospholipids. European journal of immunology, 46(8), pp. 1818-1825. Wiley-VCH 10.1002/eji.201545676

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During inflammation or under conditions of oxidative stress, the polyunsaturated fatty acid side chains of phospholipids in cellular membranes or lipoproteins can be oxidatively modified. This process generates a complex mixture of structurally diverse oxidized phospholipid (OxPL) species, each of which may exert distinct biological effects. The presence of OxPLs has been documented in acute and chronic microbial infections, metabolic disorders, and degenerative diseases. It is now well recognized that OxPLs actively influence biological processes and contribute to the induction and resolution of inflammation. While many pro- and anti-inflammatory effects have been documented for bulk OxPL preparations, we are only beginning to understand the exact molecular mechanisms and signaling events that mediate the individual proinflammatory or anti-inflammatory bioactivities of discrete isolated OxPL species. Here, we review the current knowledge on the regulation of inflammation by OxPLs and summarize recent studies that establish cyclopentenone-containing OxPLs as a category of potent anti-inflammatory lipid mediators.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Inflammatory Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology

UniBE Contributor:

Freigang, Stefan Bernd

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0014-2980

Publisher:

Wiley-VCH

Language:

English

Submitter:

Stefan Bernd Freigang

Date Deposited:

22 Dec 2016 08:08

Last Modified:

27 Sep 2017 17:06

Publisher DOI:

10.1002/eji.201545676

PubMed ID:

27312261

Uncontrolled Keywords:

Cyclopentenone; Inflammation; Isoprostane; Nrf2; Oxidized phospholipid (OxPL)

BORIS DOI:

10.7892/boris.91602

URI:

https://boris.unibe.ch/id/eprint/91602

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