Modeling the Behavior of Red Blood Cells within the Caudal Vein Plexus of Zebrafish.

Djukic, Tijana R; Karthik, Swapna; Saveljic, Igor; Djonov, Valentin; Filipovic, Nenad (2016). Modeling the Behavior of Red Blood Cells within the Caudal Vein Plexus of Zebrafish. Frontiers in physiology, 7(455), p. 455. Frontiers Research Foundation 10.3389/fphys.2016.00455

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Due to the important biological role of red blood cells (RBCs) in vertebrates, the analysis of reshaping and dynamics of RBCs motion is a critical issue in physiology and biomechanics. In this paper the behavior of RBCs within the immature capillary plexus during embryonic development of zebrafish has been analyzed. Relying on the fact that zebrafish embryos are small and optically transparent, it is possible to image the blood flow. In this way the anatomy of blood vessels is monitored along with the circulation throughout their development. Numerical simulations were performed using a specific numerical model that combines fluid flow simulation, modeling of the interaction of individual RBCs immersed in blood plasma with the surrounding fluid and modeling the deformation of individual cells. The results of numerical simulations are in accordance with the in vivo observed region of interest within the caudal vein plexus of the zebrafish embryo. Good agreement of results demonstrates the capabilities of the developed numerical model to predict and analyze the motion and deformation of RBCs in complex geometries. The proposed model (methodology) will help to elucidate different rheological and hematological related pathologies and finally to design better treatment strategies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Karthik, Swapna and Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1664-042X

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

28 Dec 2016 11:49

Last Modified:

15 Jan 2017 02:14

Publisher DOI:

10.3389/fphys.2016.00455

PubMed ID:

27774070

Uncontrolled Keywords:

blood flow; caudal vein plexus; comparison with experimental data; deformable objects; mathematical modeling; solid-fluid interation; zebrafish embryo

BORIS DOI:

10.7892/boris.91729

URI:

https://boris.unibe.ch/id/eprint/91729

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