Schmitt Kurrer, Anja; Marinoni, Ilaria; Blank, Annika; Perren, Aurel (2016). New Genetics and Genomic Data on Pancreatic Neuroendocrine Tumors: Implications for Diagnosis, Treatment, and Targeted Therapies. Endocrine pathology, 27(3), pp. 200-204. Springer 10.1007/s12022-016-9447-2
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The recent findings on the roles of death-associated protein 6/α-thalassemia/mental retardation X-linked (DAXX/ATRX) in the development of pancreatic neuroendocrine tumors (PanNETs) have led to major advances in the molecular understanding of these rare tumors and open up completely new therapeutic windows. This overview aims at giving a simplified view on these findings and their possible therapeutic implications. The importance of epigenetic changes in PanNET is also underlined by recent findings of a cross-species study on microRNA (miRNA) and messenger RNA (mRNA) profiles in PanNETs.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Schmitt Kurrer, Anja, Marinoni, Ilaria, Perren, Aurel |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1559-0097 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Aurel Perren |
Date Deposited: |
21 Dec 2016 14:13 |
Last Modified: |
05 Dec 2022 15:00 |
Publisher DOI: |
10.1007/s12022-016-9447-2 |
PubMed ID: |
27456058 |
Uncontrolled Keywords: |
Alternative lengthening of telomeres DAXX/ATRX Epigenetics Methylation Pancreatic neuroendocrine tumor Review |
BORIS DOI: |
10.7892/boris.91975 |
URI: |
https://boris.unibe.ch/id/eprint/91975 |
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