New Genetics and Genomic Data on Pancreatic Neuroendocrine Tumors: Implications for Diagnosis, Treatment, and Targeted Therapies.

Schmitt Kurrer, Anja; Marinoni, Ilaria; Blank, Annika; Perren, Aurel (2016). New Genetics and Genomic Data on Pancreatic Neuroendocrine Tumors: Implications for Diagnosis, Treatment, and Targeted Therapies. Endocrine pathology, 27(3), pp. 200-204. Springer 10.1007/s12022-016-9447-2

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The recent findings on the roles of death-associated protein 6/α-thalassemia/mental retardation X-linked (DAXX/ATRX) in the development of pancreatic neuroendocrine tumors (PanNETs) have led to major advances in the molecular understanding of these rare tumors and open up completely new therapeutic windows. This overview aims at giving a simplified view on these findings and their possible therapeutic implications. The importance of epigenetic changes in PanNET is also underlined by recent findings of a cross-species study on microRNA (miRNA) and messenger RNA (mRNA) profiles in PanNETs.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Schmitt Kurrer, Anja; Marinoni, Ilaria and Perren, Aurel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1559-0097

Publisher:

Springer

Language:

English

Submitter:

Aurel Perren

Date Deposited:

21 Dec 2016 14:13

Last Modified:

21 Dec 2016 14:13

Publisher DOI:

10.1007/s12022-016-9447-2

PubMed ID:

27456058

Uncontrolled Keywords:

Alternative lengthening of telomeres DAXX/ATRX Epigenetics Methylation Pancreatic neuroendocrine tumor Review

BORIS DOI:

10.7892/boris.91975

URI:

https://boris.unibe.ch/id/eprint/91975

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