Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

Mikocka-Walus, Antonina; Pittet, Valerie; Rossel, Jean-Benoît; Juillerat, Pascal; Tutuian, Radu; Wiest, Reiner; von Känel, Roland; Swiss IBD, Cohort Study Group (2016). Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease. Clinical gastroenterology and hepatology, 14(6), 829-835.e1. Elsevier 10.1016/j.cgh.2015.12.045

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BACKGROUND & AIMS

We examined the relationship between symptoms of depression and anxiety and clinical recurrence of inflammatory bowel disease (IBD) in a large patient cohort. We considered the progression of depression and anxiety over time.

METHODS

We collected clinical and treatment data on 2007 adult participants of the Swiss IBD study (56% with Crohn's disease [CD], 48% male) performed in Switzerland from 2006 through 2015. Depression and anxiety symptoms were quantified by using the Hospital Anxiety and Depression Scale. The relationship between depression and anxiety scores and clinical recurrence was analyzed by using survival-time techniques.

RESULTS

We found a significant association between symptoms of depression and clinical recurrence over time (for all patients with IBD, P = .000001; for subjects with CD, P = .0007; for subjects with ulcerative colitis, P = .005). There was also a significant relationship between symptoms of anxiety and clinical recurrence over time in all subjects with IBD (P = .0014) and in subjects with CD (P = .031) but not ulcerative colitis (P = .066).

CONCLUSIONS

In an analysis of a large cohort of subjects with IBD, we found a significant association between symptoms of depression or anxiety and clinical recurrence. Patients with IBD should therefore be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Psychosomatik

UniBE Contributor:

 Juillerat, Pascal, Tutuian, Radu, Wiest, Reiner, von Känel, Roland

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1542-3565

Publisher:

 Elsevier

Language:

 English

Submitter:

 Lilian Karin Smith-Wirth

Date Deposited:

 30 Mar 2017 14:38

Last Modified:

 05 Dec 2022 15:00

Publisher DOI:

 10.1016/j.cgh.2015.12.045

PubMed ID:

 26820402

Additional Information:

Christoph Müller is Member of Swiss IBD Cohort Study Group

Uncontrolled Keywords:

 CD; HADS; Mental Health; UC

BORIS DOI:

 10.7892/boris.91987

URI:

 https://boris.unibe.ch/id/eprint/91987

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