Pleomorphic rhabdomyosarcoma with an impressive response to chemotherapy: case report and review of the literature.

Kollár, Attila; Langer, Rupert; Ionescu, Codruta; Cullmann, Jennifer L.; Klenke, Frank M (2016). Pleomorphic rhabdomyosarcoma with an impressive response to chemotherapy: case report and review of the literature. Tumori, 102(Suppl.2), S57-S60. Wichtig Publishing 10.5301/tj.5000476

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PURPOSE Pleomorphic rhabdomyosarcoma (RMS) represents a rare sarcoma subtype of the adult population. Due to its clinical characteristics, treatment is currently based on the guidelines for adult soft tissue sarcoma therapy. Hence, in the metastatic setting, doxorubicin-containing regimens are used in the sarcoma community, with limited treatment benefit. Scanty published data are available on the efficacy of systemic treatment. Whether treatment response and outcome of these patients could be improved by using pediatric protocols used typically in other RMS subtypes, like embryonal and alveolar RMS, is unclear. We report on an impressive effect of multiagent pediatric chemotherapy in an adult patient with metastatic pleomorphic RMS. METHODS We present the case of a 70-year-old man with metastatic pleomorphic RMS of his left thigh. Systemic chemotherapy according to the VAC regimen (vincristine, actinomycin, cyclophosphamide) was initiated. Follow-up clinical and radiologic assessment demonstrated an impressive treatment response. RESULTS Sixteen months after primary diagnosis, computed tomography scan shows no signs of tumor progression. CONCLUSIONS Our case report emphasizes that multiagent systemic therapy according to pediatric protocols should be considered in adult patients with pleomorphic RMS.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Kollár, Attila; Langer, Rupert; Ionescu, Codruta and Cullmann, Jennifer

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2038-2529

Publisher:

Wichtig Publishing

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

22 Dec 2016 12:45

Last Modified:

27 Sep 2017 17:23

Publisher DOI:

10.5301/tj.5000476

PubMed ID:

26952562

BORIS DOI:

10.7892/boris.92028

URI:

https://boris.unibe.ch/id/eprint/92028

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