Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas.

Pouyatos, B; Nemoz, C; Chabrol, T; Potez, Marine Therese Charlette; Bräuer, E; Renaud, L; Pernet-Gallay, K; Estève, F; David, O; Kahane, P; Laissue, Jean; Depaulis, A; Serduc, R (2016). Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas. Scientific Reports, 6(27250), p. 27250. Nature Publishing Group 10.1038/srep27250

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Synchrotron-generated X-ray (SRX) microbeams deposit high radiation doses to submillimetric targets whilst minimizing irradiation of neighboring healthy tissue. We developed a new radiosurgical method which demonstrably transects cortical brain tissue without affecting adjacent regions. We made such image-guided SRX microtransections in the left somatosensory cortex in a rat model of generalized epilepsy using high radiation doses (820 Gy) in thin (200 μm) parallel slices of tissue. This procedure, targeting the brain volume from which seizures arose, altered the abnormal neuronal activities for at least 9 weeks, as evidenced by a decrease of seizure power and coherence between tissue slices in comparison to the contralateral cortex. The brain tissue located between transections stayed histologically normal, while the irradiated micro-slices remained devoid of myelin and neurons two months after irradiation. This pre-clinical proof of concept highlights the translational potential of non-invasive SRX transections for treating epilepsies that are not eligible for resective surgery.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Potez, Marine Therese Charlette and Laissue, Jean

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

David Christian Haberthür

Date Deposited:

22 Dec 2016 17:34

Last Modified:

20 Nov 2018 11:33

Publisher DOI:

10.1038/srep27250

PubMed ID:

27264273

BORIS DOI:

10.7892/boris.92119

URI:

https://boris.unibe.ch/id/eprint/92119

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