Peeping at TOMs—Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes

Mani, Jan; Meisinger, Chris; Schneider, André (2016). Peeping at TOMs—Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes. Molecular Biology and Evolution, 33(2), pp. 337-351. Oxford University Press 10.1093/molbev/msv219

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Mitochondria are essential for eukaryotic life and more than 95% of their proteins are imported as precursors from the cytosol. The targeting signals for this posttranslational import are conserved in all eukaryotes. However, this conservation does not hold true for the protein translocase of the mitochondrial outer membrane that serves as entry gate for essentially all precursor proteins. Only two of its subunits, Tom40 and Tom22, are conserved and thus likely were present in the last eukaryotic common ancestor. Tom7 is found in representatives of all supergroups except the Excavates. This suggests that it was added to the core of the translocase after the Excavates segregated from all other eukaryotes. A comparative analysis of the biochemically and functionally characterized outer membrane translocases of yeast, plants, and trypanosomes, which represent three eukaryotic supergroups, shows that the receptors that recognize the conserved import signals differ strongly between the different systems. They present a remarkable example of convergent evolution at the molecular level. The structural diversity of the functionally conserved import receptors therefore provides insight into the early evolutionary history of mitochondria.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Mani, Jan and Schneider, André

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0737-4038

Publisher:

Oxford University Press

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

24 Jan 2017 10:03

Last Modified:

02 Feb 2017 09:38

Publisher DOI:

10.1093/molbev/msv219

PubMed ID:

26474847

BORIS DOI:

10.7892/boris.92438

URI:

https://boris.unibe.ch/id/eprint/92438

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