Elucidation of the downfield spectrum of human brain at 7 T using multiple inversion recovery delays and echo times.

Fichtner, Nicole Damara; Henning, Anke; Zoelch, Niklaus; Boesch, Christoph Hans; Kreis, Roland (2017). Elucidation of the downfield spectrum of human brain at 7 T using multiple inversion recovery delays and echo times. Magnetic resonance in medicine, 78(1), pp. 11-19. Wiley-Liss 10.1002/mrm.26343

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PURPOSE To characterize the downfield spectrum at 5-10 ppm in the human brain at a high magnetic field of 7 T. Knowledge of relaxation parameters is of interest for spectroscopy as well as chemical exchange-dependent saturation transfer experiments. METHODS Water-suppressed spectra were recorded as echo time and inversion time series in healthy volunteers to investigate T2 and T1 values of downfield peaks in gray matter at 7T. The spectra were fitted in a two-dimensional fashion to a heuristic model of a series of Voigt lines, and the relaxation times were obtained for 12 peaks of interest. RESULTS The mean T2 values averaged over the volunteers ranged from 24 to 158 ms, whereas the mean T1 values ranged from 0.22 to 2.40 s. Spectra of specific inversion and echo times revealed superposition of the amide peaks of N-acetylaspartate with short T2 and an inhomogeneously broadened component with longer T2 . CONCLUSIONS T2 values were shorter than expected for most peaks, whereas T1 values had a very wide range; shorter relaxation times for some peaks suggests the presence of macromolecules. Most of the larger peaks seemed to be composed of overlapping components, because the Gaussian widths in the Voigt line shape descriptions were larger than expected based on field inhomogeneities. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Fichtner, Nicole Damara; Boesch, Christoph Hans and Kreis, Roland

ISSN:

0740-3194

Publisher:

Wiley-Liss

Language:

English

Submitter:

Christoph Hans Boesch

Date Deposited:

10 Mar 2017 12:32

Last Modified:

27 Feb 2019 09:20

Publisher DOI:

10.1002/mrm.26343

PubMed ID:

27454217

Uncontrolled Keywords:

7 T; T1 relaxation time; T2 relaxation time; human brain; metabolites; proton MR spectroscopy

BORIS DOI:

10.7892/boris.93293

URI:

https://boris.unibe.ch/id/eprint/93293

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