Tumour control and Quality of Life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy.

Leiser, Dominic; Calaminus, Gabriele; Malyapa, Robert; Bojaxhiu, Beat; Albertini, Francesca; Kliebsch, Ulrike; Mikroutsikos, Lorentzos; Morach, Petra; Bolsi, Alessandra; Walser, Marc; Timmermann, Beate; Lomax, Tony; Schneider, Ralf; Weber, Damien Charles (2016). Tumour control and Quality of Life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy. Radiotherapy and oncology, 120(1), pp. 163-168. Elsevier 10.1016/j.radonc.2016.05.013

[img] Text
1-s2.0-S0167814016311161-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (424kB) | Request a copy

PURPOSE To assess clinical outcomes in children with rhabdomyosarcoma (RMS) treated with pencil beam scanning (PBS) proton therapy (PT). METHODS AND MATERIALS Eighty-three RMS (embryonal, n=74; 89%) patients treated between January 2000 and December 2014 were included. The median age was 4.5years (range, 0.8-15.5). All patients received systemic chemotherapy according to prospective protocols. Patients had low-, intermediate-, and high-risk disease in 24%, 63%, and 13% of cases, respectively. The median total dose delivered was 54Gy(RBE) (range, 41.4-64.8). RESULTS After a median follow-up time of 55.5 months (range, 0.9-126.3), local failure occurred in 16 patients. The 5-year local-control survival rate was 78.5% [95% confidence interval (CI), 69.5-88.5%]. Significant predictors for local failure were group/stage, tumour location, and size. Fourteen patients (16%) died, all from tumour progression. The 5-year overall survival was 80.6% (95%CI, 71.8-90.0%). The 5-year incidence of grade 3 non-ocular late toxicity was 3.6% (95%CI, 1-12%). No grade 4-5 late toxicities were observed. One radiation-induced malignancy was observed (1.2%). The Quality of Life (QoL) scores increased significantly after PT compared to baseline values. CONCLUSIONS PBS PT led to excellent outcome in children with RMS. Late non-ocular toxicity was minimal and QoL good.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Leiser, Dominic; Bojaxhiu, Beat and Weber, Damien Charles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-8140

Publisher:

Elsevier

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

05 Apr 2017 08:09

Last Modified:

05 Apr 2017 08:23

Publisher DOI:

10.1016/j.radonc.2016.05.013

PubMed ID:

27247053

Uncontrolled Keywords:

Children; Late toxicity; Pencil beam scanning proton therapy; Quality of Life; Radiation-induced tumours; Rhabdomyosarcoma

BORIS DOI:

10.7892/boris.93415

URI:

https://boris.unibe.ch/id/eprint/93415

Actions (login required)

Edit item Edit item
Provide Feedback