Leiser, Dominic; Calaminus, Gabriele; Malyapa, Robert; Bojaxhiu, Beat; Albertini, Francesca; Kliebsch, Ulrike; Mikroutsikos, Lorentzos; Morach, Petra; Bolsi, Alessandra; Walser, Marc; Timmermann, Beate; Lomax, Tony; Schneider, Ralf; Weber, Damien Charles (2016). Tumour control and Quality of Life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy. Radiotherapy and oncology, 120(1), pp. 163-168. Elsevier 10.1016/j.radonc.2016.05.013
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PURPOSE
To assess clinical outcomes in children with rhabdomyosarcoma (RMS) treated with pencil beam scanning (PBS) proton therapy (PT).
METHODS AND MATERIALS
Eighty-three RMS (embryonal, n=74; 89%) patients treated between January 2000 and December 2014 were included. The median age was 4.5years (range, 0.8-15.5). All patients received systemic chemotherapy according to prospective protocols. Patients had low-, intermediate-, and high-risk disease in 24%, 63%, and 13% of cases, respectively. The median total dose delivered was 54Gy(RBE) (range, 41.4-64.8).
RESULTS
After a median follow-up time of 55.5 months (range, 0.9-126.3), local failure occurred in 16 patients. The 5-year local-control survival rate was 78.5% [95% confidence interval (CI), 69.5-88.5%]. Significant predictors for local failure were group/stage, tumour location, and size. Fourteen patients (16%) died, all from tumour progression. The 5-year overall survival was 80.6% (95%CI, 71.8-90.0%). The 5-year incidence of grade 3 non-ocular late toxicity was 3.6% (95%CI, 1-12%). No grade 4-5 late toxicities were observed. One radiation-induced malignancy was observed (1.2%). The Quality of Life (QoL) scores increased significantly after PT compared to baseline values.
CONCLUSIONS
PBS PT led to excellent outcome in children with RMS. Late non-ocular toxicity was minimal and QoL good.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Leiser, Dominic, Bojaxhiu, Beat, Weber, Damien Charles |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0167-8140 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Beatrice Scheidegger |
Date Deposited: |
05 Apr 2017 08:09 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1016/j.radonc.2016.05.013 |
PubMed ID: |
27247053 |
Uncontrolled Keywords: |
Children; Late toxicity; Pencil beam scanning proton therapy; Quality of Life; Radiation-induced tumours; Rhabdomyosarcoma |
BORIS DOI: |
10.7892/boris.93415 |
URI: |
https://boris.unibe.ch/id/eprint/93415 |
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