Management of chronic hepatitis C in 2017.

von Köckritz, Leona Isabella; Dufour, Jean-François (2017). Management of chronic hepatitis C in 2017. Hämostaseologie, 37(3), pp. 186-195. Schattauer 10.5482/HAMO-16-07-0019

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Hepatitis C virus (HCV) represents one of the most common aetiologies of chronic liver disease and causes a major global health burden. Globally an estimated 80 million people are chronically infected, but the majority of whom is still undiagnosed. Prior to the discovery of the virus in 1989 a significant number of patients were exposed and consecutively infected with HCV via contaminated transfusions, as it is a blood-borne disease. Chronic HCV infection pursues a progressive course that ultimately results in the development of cirrhosis, liver failure and hepatocellular carcinoma (HCC), if left untreated. The efficiency and tolerability of therapeutical approaches improved considerably with the development of direct-acting antivirals (DAA). The majority of patients treated with the recommended DAA combinations can be cured, which is reflected in achievement of sustained virological response (SVR). This review is intended to provide guidance in the management of patients with chronic hepatitis C, including recommendations for adequate screening, diagnostic procedures, clinical care, treatment and follow-up strategies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

von Köckritz, Leona Isabella and Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0720-9355

Publisher:

Schattauer

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

12 May 2017 11:23

Last Modified:

10 Aug 2017 01:30

Publisher DOI:

10.5482/HAMO-16-07-0019

PubMed ID:

27896359

Uncontrolled Keywords:

direct-acting antivirals; hepatitis C Virus; risk factors; sustained virological response

BORIS DOI:

10.7892/boris.93537

URI:

https://boris.unibe.ch/id/eprint/93537

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