Reliable determination of bile acids from human gallbladder by 1H MRS - protocol optimization and estimation of reproducibility

Diserens, Gaëlle; Kreis, Roland; Kröll, Dino; Nett, Philipp C.; Stirnimann, Guido; Vermathen, Peter; Wiest, Reiner (April 2017). Reliable determination of bile acids from human gallbladder by 1H MRS - protocol optimization and estimation of reproducibility. In: ISMRM 25th Annual Meeting & Exhibition. Honolulu, Hawaii. April 2017.

[img] Text
Reliable determination.pdf - Accepted Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (171kB)

Bile exerts multiple functions in the liver and gut with a crucial role for triglyceride-, sterol- and carbohydrate-metabolism and is a key player in disease processes. The study purpose was to develop a reliable MRS protocol and to assess variability of bile acid determination in human gallbladder. Our study demonstrated higher stability and reliability of gallbladder spectra with subjects measured in prone position compared to back position. Relatively small coefficients of variation were obtained in a reproducibility study particularly within subjects, suggesting clinical applicability of the method, especially for longitudinal studies.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Diserens, Gaëlle; Kreis, Roland; Kröll, Dino; Nett, Philipp C.; Stirnimann, Guido; Vermathen, Peter and Wiest, Reiner

Subjects:

600 Technology > 610 Medicine & health

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

17 Jan 2018 11:43

Last Modified:

17 Jan 2018 12:34

Related URLs:

BORIS DOI:

10.7892/boris.94605

URI:

https://boris.unibe.ch/id/eprint/94605

Actions (login required)

Edit item Edit item
Provide Feedback