Closed-loop for type 1 diabetes - an introduction and appraisal for the generalist.

Bally, Lia; Thabit, Hood; Hovorka, Roman (2017). Closed-loop for type 1 diabetes - an introduction and appraisal for the generalist. BMC medicine, 15(1), p. 14. BioMed Central 10.1186/s12916-017-0794-8

[img] Text
s12916-017-0794-8 - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (532kB)


Rapid progress over the past decade has been made with the development of the 'Artificial Pancreas', also known as the closed-loop system, which emulates the feedback glucose-responsive functionality of the pancreatic beta cell. The recent FDA approval of the first hybrid closed-loop system makes the Artificial Pancreas a realistic therapeutic option for people with type 1 diabetes. In anticipation of its advent into clinical care, we provide a primer and appraisal of this novel therapeutic approach in type 1 diabetes for healthcare professionals and non-specialists in the field.


Randomised clinical studies in outpatient and home settings have shown improved glycaemic outcomes, reduced risk of hypoglycaemia and positive user attitudes. User input and interaction with existing closed-loop systems, however, are still required. Therefore, management of user expectations, as well as training and support by healthcare providers are key to ensure optimal uptake, satisfaction and acceptance of the technology. An overview of closed-loop technology and its clinical implications are discussed, complemented by our extensive hands-on experience with closed-loop system use during free daily living.


The introduction of the artificial pancreas into clinical practice represents a milestone towards the goal of improving the care of people with type 1 diabetes. There remains a need to understand the impact of user interaction with the technology, and its implication on current diabetes management and care.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bally, Lia Claudia


600 Technology > 610 Medicine & health




BioMed Central




Lia Bally

Date Deposited:

18 Jul 2017 10:36

Last Modified:

05 Dec 2022 15:02

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Artificial pancreas; Closed-loop; Glucose control; Type 1 diabetes




Actions (login required)

Edit item Edit item
Provide Feedback