Effects of a transdiagnostic unguided Internet intervention (‘velibra’) for anxiety disorders in primary care: results of a randomized controlled Trial.

Berger, T.; Urech, A.; Krieger, T.; Stolz, T.; Schulz, A.; Vincent, A.; Moser, C. T.; Moritz, S.; Meyer, B. (2017). Effects of a transdiagnostic unguided Internet intervention (‘velibra’) for anxiety disorders in primary care: results of a randomized controlled Trial. Psychological medicine, 47(1), pp. 67-80. Cambridge University Press 10.1017/S0033291716002270

effects_of_a_transdiagnostic_unguided_internet_intervention_velibra_for_anxiety_disorders_in_primary_care_results_of_a_randomized_controlled_trial.pdf - Published Version
Available under License Publisher holds Copyright.

Download (318kB) | Preview

Internet-based cognitive–behavioural treatment (ICBT) for anxiety disorders has shown some promise, but no study has yet examined unguided ICBT in primary care. This randomized controlled trial (RCT) investigated whether a transdiagnostic, unguided ICBT programme for anxiety disorders is effective in primary care settings, after a face-to-face consultation with a physician (MD). We hypothesized that care as usual (CAU) plus unguided ICBT would be superior to CAU in reducing anxiety and related symptoms among patients with social anxiety disorder (SAD), panic disorder with or without agoraphobia (PDA) and/or generalized anxiety disorder (GAD).
Adults (n = 139) with at least one of these anxiety disorders, as reported by their MD and confirmed by a structured diagnostic interview, were randomized. Unguided ICBT was provided by a novel transdiagnostic ICBT programme (‘velibra’). Primary outcomes were generic measures, such as anxiety and depression symptom severity, and diagnostic status at post-treatment (9 weeks). Secondary outcomes included anxiety disorder-specific measures, quality of life, treatment adherence, satisfaction, and general psychiatric symptomatology at follow-up (6 months after randomization).
CAU plus unguided ICBT was more effective than CAU at post-treatment, with small to medium between-group effect sizes on primary (Cohen's d = 0.41–0.47) and secondary (Cohen's d = 0.16–0.61) outcomes. Treatment gains were maintained at follow-up. In the treatment group, 28.2% of those with a SAD diagnosis, 38.3% with a PDA diagnosis, and 44.8% with a GAD diagnosis at pretreatment no longer fulfilled diagnostic criteria at post-treatment.
The unguided ICBT intervention examined is effective for anxiety disorders when delivered in primary care.

Item Type:

Journal Article (Original Article)


07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

Berger, Thomas (B), Urech, Antoine Jan, Krieger, Tobias, Stolz, Timo Johannes, Schulz, Ava, Vincent, Alessia Michelle, Moser, Christian Thomas


600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology




Cambridge University Press


[4] Swiss National Science Foundation




Thomas Berger

Date Deposited:

19 Jul 2017 15:10

Last Modified:

29 Mar 2023 23:35

Publisher DOI:


PubMed ID:






Actions (login required)

Edit item Edit item
Provide Feedback