Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study.

Haider, Dominik; Lindner, Gregor; Wolzt, Michael; Leichtle, Alexander Benedikt; Fiedler, Martin; Sauter, Thomas; Fuhrmann, Valentin; Exadaktylos, Aristomenis (2016). Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study. Journal of negative results in biomedicine, 15(1), p. 1. BioMed Central 10.1186/s12952-016-0044-1

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BACKGROUND Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality. METHODS In this cross sectional analysis, all emergency room patients 2010 and 2011 at the Inselspital Bern, Switzerland were included. A multivariable logistic regression model was performed to assess the association between pre-existing diuretic medication and 28 day mortality. RESULTS Twenty-two thousand two hundred thirty-nine subjects were included in the analysis. A total of 8.5%, 2.5%, and 0.4% of patients used one, two, or three or more diuretics. In univariate analysis spironolactone, torasemide and chlortalidone use were associated with 28 day mortality (all p < 0.05). In a multivariate cox regression model no association with mortality was detectable (p > 0.05). No difference existed between patients with or without diuretic therapy (P > 0.05). Age and creatinine were independent risk factors for mortaliy (both p < 0.05). CONCLUSION Use of diuretics is not associated with mortality in an unselected cohort of patients presenting in an emergency room.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Haider, Dominik; Leichtle, Alexander Benedikt; Fiedler, Martin; Sauter, Thomas and Exadaktylos, Aristomenis

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1477-5751

Publisher:

BioMed Central

Language:

English

Submitter:

Romana Saredi

Date Deposited:

10 Feb 2017 08:47

Last Modified:

12 Feb 2017 02:14

Publisher DOI:

10.1186/s12952-016-0044-1

PubMed ID:

26832747

BORIS DOI:

10.7892/boris.94958

URI:

https://boris.unibe.ch/id/eprint/94958

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