Correlating HIV tropism with immunological response under combination antiretroviral therapy

Bader, J; Schöni-Affolter, F; Böni, J; Gorgievski, Meri; Martinetti, G; Battegay, M; Klimkait, T; Swiss HIV Cohort, Study (2016). Correlating HIV tropism with immunological response under combination antiretroviral therapy. HIV medicine, 17(8), pp. 615-622. Blackwell Science 10.1111/hiv.12365

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OBJECTIVES A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART). It is still unclear whether viral properties such as cell tropism play a major role in this incomplete immune response. This study therefore intended to follow the tropism evolution of the HIV-1 envelope during periods of suppressive cART. METHODS Viruses from two distinct patient groups, one with good and another one with poor CD4 recovery after 5 years of suppressive cART, were genotypically analysed for viral tropism at baseline and at the end of the study period. RESULTS Patients with CCR5-tropic CC-motif chemokine receptor 5 viruses at baseline tended to maintain this tropism to the study end. Patients who had a CXCR4-tropic CXC-motif chemokine receptor 4 virus at baseline were overrepresented in the poor CD4 recovery group. Overall, however, the majority of patients presented with CCR5-tropic viruses at follow-up. CONCLUSIONS Our data lend support to the hypothesis that tropism determination can be used as a parameter for disease progression even if analysed long before the establishment of a poorer immune response. Moreover, the lasting predominating CCR5-tropism during periods of full viral control suggests the involvement of cellular mechanisms that preferentially reduce CXCR4-tropic viruses during cART.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Gorgievski, Meri

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1464-2662

Publisher:

Blackwell Science

Language:

English

Submitter:

Siegfried Hektor Hapfelmeier-Balmer

Date Deposited:

16 Mar 2017 17:50

Last Modified:

04 Jul 2017 14:52

Publisher DOI:

10.1111/hiv.12365

PubMed ID:

26991140

Uncontrolled Keywords:

HIV; antiretroviral therapy; combination; immune response; tropism

BORIS DOI:

10.7892/boris.95176

URI:

https://boris.unibe.ch/id/eprint/95176

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