Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response.

Kindler, Eveline Patricia; Thiel, Volker Earl; Weber, F (2016). Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Advances in virus research, 96, pp. 219-243. Elsevier 10.1016/bs.aivir.2016.08.006

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Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Kindler, Eveline Patricia and Thiel, Volker Earl

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

1557-8399

Publisher:

Elsevier

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

07 Jul 2017 14:38

Last Modified:

07 Jul 2017 14:38

Publisher DOI:

10.1016/bs.aivir.2016.08.006

PubMed ID:

27712625

Uncontrolled Keywords:

Interferon; MDA5; MERS-CoV; PKR; RIG-I-like receptors; SARS-CoV; Viral countermeasures

URI:

https://boris.unibe.ch/id/eprint/96154

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