SARS-CoV and IFN: Too Little, Too Late.

Kindler, Eveline Patricia; Thiel, Volker Earl (2016). SARS-CoV and IFN: Too Little, Too Late. Cell host & microbe, 19(2), pp. 139-141. Cell Press 10.1016/j.chom.2016.01.012

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Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopathology, with fatal outcomes.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Kindler, Eveline Patricia and Thiel, Volker Earl

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

1931-3128

Publisher:

Cell Press

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

21 Jul 2017 12:45

Last Modified:

21 Jul 2017 12:45

Publisher DOI:

10.1016/j.chom.2016.01.012

PubMed ID:

26867172

BORIS DOI:

10.7892/boris.96176

URI:

https://boris.unibe.ch/id/eprint/96176

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